Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat.

نویسندگان

  • A C van der Ham
  • W J Kort
  • I M Weijma
  • H F van den Ingh
  • H Jeekel
چکیده

In 90 rats a colonic anastomosis was constructed with 12 interrupted 7/0 polypropylene sutures. Group 1 (n = 30) served as a control group. In group 2 (n = 30) the anastomosis was sealed with fibrin adhesive and in group 3 (n = 30) a mixture of fibrin, clindamycin and cefotaxime was used. On days 2, 4 and 7, ten animals in each group were killed. Adhesion formation was significantly increased in groups 2 and 3 compared with the control group. On day 2 the anastomosis was significantly stronger after sealing with antibiotic-fibrin mixture. On day 4 the bursting pressure in group 2 was significantly lower than in groups 1 and 3. At the same time the concentration of hydroxyproline was significantly reduced in group 2, but not in group 3. The addition of antibiotics prevents the negative effect of fibrin adhesive on the healing colonic anastomosis and contributes to a stronger anastomosis on day 2 after operation.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

[Determination of fibrin glue with antibiotics on collagen production in colon anastomosis].

BACKGROUND/AIM Fibrin glue is used as a matrix for local application of antibiotics. The aim of this study was to determine whether application of fibrin glue in combination with antibiotics can strengthen collagen production, prevent dehiscence of colon anastomoses due to infection, and reduce frequency of mortality and morbidity comparing to the control group and the group with fibrin glue ap...

متن کامل

Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses

OBJECTIVE Fibrin glues have not been consistently successful in preventing the dehiscence of high-risk colonic anastomoses. Fibrinogen and thrombin concentrations in glues determine their ability to function as sealants, healers, and/or adhesives. The objective of the current study was to compare the effects of different concentrations of fibrinogen and thrombin on bursting pressure, leaks, deh...

متن کامل

Evaluating the Feasibility of Esophagotomy Suture Line Reinforcement Using Platelet Rich Fibrin Membrane and Its Effect on Wound Healing

Objective- This study aimed to evaluate the feasibility of using platelet rich fibrin membrane as a novel on-lay patching biomaterial in canine esophagotomy and its effects on esophageal wound healing. Design- Experimental study. Animals- Eight adult mixed breed dogs of both sexes equally allocated to control and treatment groups.<b...

متن کامل

Influence of sealant fibrin on the wound healing of the pigs vocal folds.

UNLABELLED Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space. ...

متن کامل

The effect of fibrin sealant on the healing of laser-resurfaced skin.

BACKGROUND Fibrin sealant is an effective hemostatic agent and a useful tissue sealant. Studies have also suggested that fibrin sealant may accelerate the normal wound-healing process. OBJECTIVE This study was designed to ascertain whether fibrin sealant would enhance wound healing after CO(2) laser resurfacing in a guinea pig model. METHODS The CO(2) laser was used to create equal areas of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The British journal of surgery

دوره 79 6  شماره 

صفحات  -

تاریخ انتشار 1992